Is Melatonin Good for Anxiety?

Stressful life events, especially that which we are currently experiencing, are associated with the onset of major mental health disorders, including anxiety and major depression.

Subsequently, many people have turned to prescription medication to alleviate the symptoms of these psychiatric disorders. Unfortunately, the majority of prescription anti-anxiety and antidepressant medications can have significant and unpleasant side effects. But there are several alternatives that may help; these include CBD sleep drops, Honey Citrus Tea and Melatonin, and CBD Gummies available from ShopCBD.

Melatonin has been touted as a miracle hormone for many years. Along with its well-known uses in increasing the quality and quantity of sleep, melatonin also exerts strong beneficial effects in mental health disorders, cancer, endotoxic shock, non-septic shock, anxiety, and depression.

This may be news to a number of us who traditionally know melatonin as a sedative and sleeping aid. Therefore several questions need to be answered. Firstly, what is melatonin? Secondly, how does melatonin work? Lastly, are there any beneficial combinations out there that can enhance melatonin's benefits for anxiety and depression? Let’s find out.

What Is Melatonin?

Melatonin is the secretory product of the pineal gland in humans, a pea-sized region of the brain, has been the center of much scientific research for the past several decades. melatonin has been found to not only be produced by humans but other vertebrates, invertebrates, and all the way down to plants.

Melatonin follows a very strict day to night cycle, with expression being the highest at night time. This cyclic secretion of melatonin is why our bodies want us to sleep at night. However, this super-hormone does not stop there. It has a significant influence over our body's processes, including reproduction, body temperature, behavioral performance, and aging.

Not only does melatonin have a significant influence over bodily processes, but it also modulates our mood.

Many studies have found that melatonin is particularly useful in treating sickness behavior, such as anxiety, when we are exposed to nasty infections.

This anti-anxiety effect also extends to those who have anxiety and depression due to neurological conditions such as Alzheimer's disease, major depression, and other mood disorders. Melatonin is also useful for those who are particularly anxious around certain medical procedures such as surgery. But how does it actually work?

How Does Melatonin Work?

Melatonin is referred to as an endogenous indoleamine. Don’t worry if that went over your head; in a nutshell, this means melatonin is a neurotransmitter produced in the body. When the pineal gland produces melatonin, it is not stored but instead secreted into the blood and makes its way throughout the body.

The physiological and pharmacological properties of melatonin have been extensively studied over the past few years. From this, it is known that melatonin has several incredibly important functions, including regulating behavior and the stress response.

Melatonin can regulate our behavior through several pathways, two of which we will look at in more detail.

Firstly, melatonin can regulate how excited our hippocampus gets during stress. The hippocampus is the brain region responsible for cognition, locomotion, learning, and memory. However, when it becomes over-excited, it results in us being particularly vulnerable to behavioral changes associated with depression and anxiety.

Secondly, melatonin can regulate how much dopamine is expressed in our hippocampus. When we become particularly stressed, dopamine levels in the brain decrease, this decrease in dopamine reduces our pleasure pathway, resulting in anxiety and depressive symptoms. When higher melatonin levels are present, it stimulates the brain to make more dopamine, resulting in reduced anxiety and depression-related symptoms.

Melatonin obviously has a significant effect on how we think, feel, and behave, but how could we enhance melatonin's anti-anxiety and antidepressant properties? This is where CBD comes in.

CBD and Melatonin, a Combination Good for Anxiety?

Along with melatonin, CBD is well known for its anti-anxiety powers. CBD acts on the body through the endocannabinoid system. This is made up of two major CBD receptors, CB1 and CB2. These receptors are located in several tissues throughout the body, including the brain.

CBD has an indirect effect on CB1 receptors. CBD inhibits the breakdown of anandamide (ANA), allowing it to stay in the body longer, providing a range of health benefits. Anandamide regulates neurotransmitters such as dopamine and serotonin and it's thought CBD may help regulate these mood-related hormones through slowing the breakdown of anandamide.

CBD also directly affects the 5-HT1A serotonin receptor at higher doses, which appears to cause an antidepressant effect.

The action of CBD complements that of melatonin. Both are major regulators of the “feel-happy” neurotransmitters, such as dopamine and serotonin, and both regulate the excitability of the hippocampus. Together, CBD and melatonin make quite a formidable team against anxiety and depression.

In addition to helping melatonin combat anxiety and depression, the endocannabinoid system does not interfere with melatonin's synthesis in the brain's pineal gland. This means that CBD will not interfere with melatonin production. Moreover, melatonin does not interfere with CBD and its two major receptors, CB1 and CB2.

In addition to their anti-anxiety effects, melatonin and CBD can help promote a good night's sleep. Melatonin exerts a more regulated and sedating effect, while CBD reduces disturbances in sleep often associated with anxiety, depression, insomnia, and post-traumatic stress disorder.

CBD and Melatonin Products

If you are looking for a place to buy some of the best melatonin and CBD combinations, look no further than ShopCBD. ShopCBD has a range of high-quality products that combine CBD and melatonin, to ensure you can reduce your stress levels and sleep better.


CBD Oil Sleep 500mg Mint by cbdMD

cbdMD CBD oil Sleep drops

If you are looking to improve your mood, stress, and sleep, it is time to try these wonderful CBD sleep drops available from ShopCBD. Together with a high concentration of high-quality CBD and melatonin, these drops are perfect for helping you get on your way to remove the stress in your life with a deep and restorative sleep.


CBD Dreamy Honey Citrus Tea 10 count 200mg by Zolt

Zolt - Dreamy

If you need help to boost your mood Honey Citrus Tea is for you. Available at ShopCBD, this calming drink combines CBD's power with melatonin and stress-relieving adaptogen herbs such as Ashwagandha.


Melatonin CBD Gummies 300mg 60ct by CBDfx

CBDfx Melatonin Gummies

Becoming anxious about the new stressors 2020 brings? Then look no further than these amazing Melatonin and CBD Gummies available at ShopCBD. These gummies combine CBD's anti-anxiety powers with the miracle-hormone melatonin to help you sleep better (and best of all it’s completely free of THC).


Key Takeaways

Melatonin has long been considered a miracle hormone. It has a significant regulatory effect on many bodily processes, including regulating mood, increasing the amount of “feel-happy” neurotransmitters, aiding the quality and quantity of our sleep, and reducing symptoms of depression and anxiety. Together with CBD's anti-anxiety powers, this duo is coming up in the ranks as the new batman and robin of the anti-anxiety world.